Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 18/20 | 0.35 |
| ▸ | RARB | P10826 | 9/20 | 0.35 |
| ▸ | RARG | P13631 | 8/20 | 0.35 |
| ▸ | RXRB | P28702 | 4/20 | 0.35 |
| ▸ | RXRG | P48443 | 4/20 | 0.35 |
| ▸ | RARA | P10276 | 4/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812219 | 0.89 | RXRA (0.43) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL8423718 | 0.83 | CYP3A4 (0.38) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7816750 | 0.82 | RXRA (0.33) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7806225 | 0.77 | RARA (0.34) | RXRARARBRARGRXRGRARA | |
| SCHEMBL7812405 | 0.77 | CYP26A1 (0.43) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7813043 | 0.77 | RARA (0.34) | RXRARARBRARGRXRGRARA | |
| SCHEMBL7810811 | 0.77 | CYP26A1 (0.43) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7816747 | 0.76 | RXRA (0.37) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7816745 | 0.76 | RXRA (0.37) | RXRARARBRARGRXRBRXRG | |
| SCHEMBL7805839 | 0.75 | RARB (0.32) | RXRARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0816352-B1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CT INTERNAT DE (FR) | 2001-02-21 | — | — | EP | claimed |
| EP-0816352-B1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CT INTERNAT DE (FR) | 2001-02-21 | — | — | EP | disclosed |
| EP-0816352-A1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1998-01-07 | — | — | EP | disclosed |