Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 2/20 | 0.43 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 13/20 | 0.40 |
| ▸ | RARA | P10276 | 4/20 | 0.39 |
| ▸ | RARB | P10826 | 4/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810811 | 1.00 | CYP26A1 (0.43) | CYP26A1CYP26B1CYP3A4RXRARARA | |
| SCHEMBL7805839 | 0.84 | RARB (0.32) | RXRARARB | |
| SCHEMBL7816745 | 0.81 | RXRA (0.37) | CYP26A1CYP3A4RXRARARARARB | |
| SCHEMBL7816747 | 0.81 | RXRA (0.37) | CYP26A1CYP3A4RXRARARARARB | |
| SCHEMBL7812219 | 0.81 | RXRA (0.43) | RXRARARARARBRXRGRXRB | |
| SCHEMBL7812403 | 0.77 | RXRA (0.35) | CYP26A1CYP26B1RXRARARARARB | |
| SCHEMBL7806225 | 0.76 | RARA (0.34) | CYP26A1CYP3A4RXRARARARARB | |
| SCHEMBL7813043 | 0.76 | RARA (0.34) | CYP26A1CYP3A4RXRARARARARB | |
| SCHEMBL8423718 | 0.76 | CYP3A4 (0.38) | CYP26A1CYP3A4RXRARARARARB | |
| SCHEMBL7816750 | 0.75 | RXRA (0.33) | CYP26A1CYP26B1RXRARARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0816352-B1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CT INTERNAT DE (FR) | 2001-02-21 | — | — | EP | claimed |
| US-5905088-A | SKIN DISORDERS, RHEUMATIC DISEASES, RESPIRATORY SYSTEM OR CARDIOVASCULAR DISORDERS AND OPTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-05-18 | — | — | US | claimed |
| EP-0816352-B1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CT INTERNAT DE (FR) | 2001-02-21 | — | — | EP | disclosed |
| US-5905088-A | SKIN DISORDERS, RHEUMATIC DISEASES, RESPIRATORY SYSTEM OR CARDIOVASCULAR DISORDERS AND OPTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-05-18 | — | — | US | disclosed |
| EP-0816352-A1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1998-01-07 | — | — | EP | disclosed |