SCHEMBL7812867

SCHEMBL7812867

CN1CCCCC1c1cccc2ccccc12

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 4/20 0.52
CHRNA4 P43681 4/20 0.52
SLC6A4 P31645 2/20 0.49
DRD2 P14416 1/20 0.49
CHRNA7 P36544 2/20 0.49
CHRNB4 P30926 1/20 0.49
CHRNA3 P32297 1/20 0.49
HTR2A P28223 1/20 0.48
HTR2C P28335 1/20 0.48
KCNH2 Q12809 1/20 0.48
CHRM1 P11229 1/20 0.46
EGFR P00533 1/20 0.43
ERBB2 P04626 1/20 0.43
HRH3 Q9Y5N1 1/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A3 Q01959 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7572411 0.83 CHRNB2 (0.40) CHRNB2CHRNA4DRD2CHRNA7CHRNB4
SCHEMBL9325734 0.81 MTNR1A (0.50) CHRNB4CHRNA3
SCHEMBL1645816 0.80 EGFR (0.43) SLC6A4DRD2EGFRERBB2HRH3
SCHEMBL15830280 0.78 CHRNB2 (0.53) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL7571886 0.78 CHRNB2 (0.44) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL10681131 0.77 EGFR (0.41) SLC6A4DRD2CHRM1EGFRERBB2
SCHEMBL28607372 0.77 DRD2 (0.43) SLC6A4DRD2EGFRERBB2
SCHEMBL24774514 0.77 CHRNB2 (0.51) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL11327692 0.77 CHRNB2 (0.51) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3
SCHEMBL11571005 0.77 CHRNB2 (0.51) CHRNB2CHRNA4CHRNA7CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1106605-A1 ALPHA1B-ADRENERGIC RECEPTOR ANTAGONISTS TORAY INDUSTRIES, INC. (JP) 2001-06-13 EP disclosed
US-4246268-A ANTIPSYCHOTICS, TRANQUILIZERS, NEUROLEPTICS COMPOUNDS AND NOVEL INTERMEDIATES RICHARDSON-MERRELL INC. (US) 1981-01-20 US disclosed