Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 4/20 | 0.49 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 5/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.41 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 5/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7806106 | 0.89 | HSPA5 (0.49) | HSPA5HSPA2CTSLCTSBCTSS | |
| SCHEMBL6620163 | 0.86 | HSPA5 (0.49) | HSPA5HSPA2CTSLCTSBCTSS | |
| SCHEMBL7609373 | 0.85 | HSPA5 (0.49) | HSPA5HSPA2CTSLCTSBCTSS | |
| SCHEMBL7819471 | 0.82 | REN (0.47) | CTSLCTSBCTSSCTSKCTSD | |
| SCHEMBL7470442 | 0.73 | CTSL (0.47) | CTSLCTSBCTSSCTSKPSMB5 | |
| SCHEMBL7830243 | 0.73 | CTSK (0.39) | CTSLCTSBCTSSCTSKSCN9A | |
| SCHEMBL14345770 | 0.73 | TAS1R3 (0.50) | CTSLCTSBCTSSCTSKCNR2 | |
| SCHEMBL7467592 | 0.72 | TAS1R3 (0.49) | CTSLCTSBCTSSCTSKCNR2 | |
| SCHEMBL7612563 | 0.72 | CTSL (0.37) | HSPA5HSPA2CTSLCTSBCTSS | |
| SCHEMBL7463889 | 0.72 | CTSL (0.49) | CTSLCTSBCTSSCTSKPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068304-A4 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORP (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1068304-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999053039-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |