Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30356302 | 1.00 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL11166274 | 0.86 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL11704484 | 0.84 | KCNQ2 (0.44) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL5898502 | 0.84 | MAPT (0.47) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL2942491 | 0.82 | KCNQ2 (0.50) | ALDH1A1SMN1; SMN2GAAMAPTKDM4E | |
| SCHEMBL30356288 | 0.80 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL7500203 | 0.79 | GAA (0.54) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL7593748 | 0.79 | L3MBTL1 (0.71) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL30356289 | 0.77 | KMT2A (0.43) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL9576991 | 0.75 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1SMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1152759-A2 | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047194-A9 | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR | DIMENSIONAL PHARM INC (US) | 2001-05-31 | — | — | WO | disclosed |
| WO-2000047194-A2 | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |