Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 3/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1905412 | 0.85 | ALOX5 (0.38) | SLC6A12SLC6A11SLC6A13ALOX5KMT2A | |
| SCHEMBL7739796 | 0.82 | SLC6A12 (0.60) | SLC6A12SLC6A11SLC6A13THRBMEN1 | |
| SCHEMBL7740219 | 0.82 | SLC6A12 (0.60) | SLC6A12SLC6A11SLC6A13THRBMEN1 | |
| SCHEMBL7739792 | 0.82 | SLC6A12 (0.60) | SLC6A12SLC6A11SLC6A13THRBMEN1 | |
| SCHEMBL7740218 | 0.82 | SLC6A12 (0.60) | SLC6A12SLC6A11SLC6A13THRBMEN1 | |
| SCHEMBL30445198 | 0.82 | SLC6A12 (0.60) | SLC6A12SLC6A11SLC6A13THRBMEN1 | |
| SCHEMBL3109773 | 0.82 | SLC6A12 (0.60) | SLC6A12SLC6A11SLC6A13THRBMEN1 | |
| SCHEMBL1905506 | 0.80 | ALOX5 (0.38) | SLC6A12SLC6A11SLC6A13ALOX5KMT2A | |
| SCHEMBL24260428 | 0.80 | SLC6A12 (0.37) | SLC6A12SLC6A11SLC6A13THRBMEN1 | |
| SCHEMBL5499821 | 0.77 | CA1 (0.40) | ALOX5TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6320051-B1 | AMINO(NH) OR OXYGEN(O) SUBSTITUTED, ENZYME INHIBITORS OF STAPHLOCCOCUS AUREUS METHIONYL T-RNA SYNTHETASE (MRS); ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2001-11-20 | — | — | US | disclosed |
| CN-1307565-A | Quinolones used as MRS inhibitor and bactericides | SMITHKLINE BEECHAM PLC (GB) | 2001-08-08 | — | — | CN | disclosed |
| EP-1084110-A1 | QUINOLONES USED AS MRS INHIBITORS AND BACTERICIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999055677-A1 | QUINOLONES USED AS MRS INHIBITORS AND BACTERICIDES | SMITHKLINE BEECHAM PLC (GB) | 1999-11-04 | — | — | WO | disclosed |