Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 6/20 | 0.60 |
| ▸ | SLC6A13 | Q9NSD5 | 6/20 | 0.60 |
| ▸ | SLC6A11 | P48066 | 5/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.32 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739792 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL3109773 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL7739796 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL30445198 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL7740218 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL7410374 | 0.95 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL3742078 | 0.95 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL28777375 | 0.86 | — | — | |
| SCHEMBL11051978 | 0.83 | SLC6A12 (0.52) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL7814549 | 0.82 | SLC6A12 (0.38) | SLC6A12SLC6A13SLC6A11THRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |