Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 6/20 | 0.60 |
| ▸ | SLC6A13 | Q9NSD5 | 6/20 | 0.60 |
| ▸ | SLC6A11 | P48066 | 5/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 5/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.32 |
| ▸ | PEPD | P12955 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739792 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL3109773 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL7740219 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL7739796 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL30445198 | 1.00 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL7410374 | 0.95 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL3742078 | 0.95 | SLC6A12 (0.60) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL28777375 | 0.86 | — | — | |
| SCHEMBL11051978 | 0.83 | SLC6A12 (0.52) | SLC6A12SLC6A13SLC6A11GABRA5GABRB2 | |
| SCHEMBL7814549 | 0.82 | SLC6A12 (0.38) | SLC6A12SLC6A13SLC6A11THRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392196-A1 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2020-12-17 | — | — | US | disclosed |
| US-10793615-B2 | Long-acting co-agonists of the glucagon and GLP-1 receptors | MERCK SHARP & DOHME CORP. (US) | 2020-10-06 | — | — | US | disclosed |
| WO-2017074798-A2 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2017-05-04 | — | — | WO | disclosed |
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10793615-B2 | Long-acting co-agonists of the glucagon and GLP-1 receptors | GLP1R, GCGR, GIPR | SLC6A12 2485/4885SLC6A13 1309/4885SLC6A11 1381/4885 |
| US-20200392196-A1 | LONG-ACTING CO-AGONISTS OF THE GLUCAGON AND GLP-1 RECEPTORS | GLP1R, GCGR, GIPR | SLC6A12 2485/4885SLC6A13 1309/4885SLC6A11 1381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.