SCHEMBL7814766

SCHEMBL7814766

Cc1cc(N)n(-c2ncc(C(F)(F)F)cc2Cl)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.52
ATM Q13315 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.50
RECQL P46063 1/20 0.50
SMN1; SMN2 Q16637 5/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
PKM P14618 1/20 0.47
POLB P06746 2/20 0.47
LMNA P02545 1/20 0.45
GABRP O00591 1/20 0.45
GABRD O14764 1/20 0.45
GABRA1 P14867 1/20 0.45
GABRB1 P18505 1/20 0.45
GABRG2 P18507 1/20 0.45
GABRB3 P28472 1/20 0.45
GABRA5 P31644 1/20 0.45
GABRA3 P34903 1/20 0.45
GABRA2 P47869 1/20 0.45
GABRB2 P47870 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19086927 0.81 GAA (0.52) GAAATML3MBTL1RECQLSMN1; SMN2
SCHEMBL2004433 0.80 L3MBTL1 (0.45) GAAATML3MBTL1RECQLSMN1; SMN2
SCHEMBL6168749 0.80 GABRB3 (0.68) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL7459920 0.77 GAA (0.47) GAAATML3MBTL1RECQLSMN1; SMN2
SCHEMBL23302308 0.77 GAA (0.51) GAAATML3MBTL1RECQLSMN1; SMN2
SCHEMBL7692554 0.76 GAA (0.46) GAAATML3MBTL1RECQLSMN1; SMN2
SCHEMBL15125479 0.76 GAA (0.46) GAAATML3MBTL1RECQLSMN1; SMN2
SCHEMBL15962338 0.76 GAA (0.46) GAAATML3MBTL1RECQLSMN1; SMN2
SCHEMBL14996685 0.76 GAA (0.53) GAAATML3MBTL1RECQLSMN1; SMN2
SCHEMBL4539912 0.76 KMT2A (0.50) GAAATML3MBTL1RECQLSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871617-B1 PARASITICIDAL COMPOUNDS PFIZER (US) 2001-11-14 EP disclosed
US-6255333-B1 HUMANS OR ANIMALS PFIZER INC. 2001-07-03 US disclosed