Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 4/20 | 0.43 |
| ▸ | GABRD | O14764 | 4/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.43 |
| ▸ | GABRE | P78334 | 4/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239495 | 0.82 | GABRB3 (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| Ammonia Solution, Strong SCHEMBL8425567 | 0.81 | GABRB3 (0.59) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7814766 | 0.80 | GAA (0.52) | L3MBTL1POLBGAAATMGABRP | |
| SCHEMBL14615157 | 0.78 | GABRB3 (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2837550 | 0.78 | GABRA2 (0.44) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2835184 | 0.78 | GABRA2 (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6475236 | 0.77 | KDM4E (0.49) | L3MBTL1POLBGAAATMGABRP | |
| SCHEMBL7028502 | 0.77 | GABRB3 (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30693085 | 0.77 | GABRB3 (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6965080 | 0.77 | GABRP (0.47) | L3MBTL1POLBGAAATMGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084486-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-12-27 | — | — | US | disclosed |
| US-20110196011-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2011-08-11 | — | — | US | disclosed |
| US-7960426-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-06-14 | — | — | US | disclosed |
| US-7902232-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2011-03-08 | — | — | US | disclosed |
| US-20090312371-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2009-12-17 | — | — | US | disclosed |
| US-20090137524-A1 | SUBSTITUTED ARYLPYRAZOLES | ZOETIS SERVICES LLC | 2009-05-28 | — | — | US | disclosed |
| US-7514464-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2009-04-07 | — | — | US | disclosed |
| EP-1705989-B8 | SUBSTITUTED ARYLPYRAZOLES AS PARASITICIDAL AGENTS | PFIZER LTD (GB) | 2009-03-25 | — | — | EP | disclosed |
| EP-1705989-B1 | SUBSTITUTED ARYLPYRAZOLES AS PARASITICIDAL AGENTS | PFIZER LTD (GB) | 2008-11-12 | — | — | EP | disclosed |
| US-7435753-B2 | Substituted arylpyrazoles | PFIZER LIMITED (GB) | 2008-10-14 | — | — | US | disclosed |
| EP-0933363-B1 | Parasiticidal pyrazoles | PFIZER LTD (GB) | 2003-08-27 | — | — | EP | disclosed |
| EP-0946515-B1 | PARASITICIDAL PYRAZOLES | PFIZER LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-20020173662-A1 | Parasiticidal pyrazoles | BANKS BERNARD JOSEPH (GB) | 2002-11-21 | — | — | US | disclosed |
| US-6268509-B1 | PESTICIDES | PFIZER INC | 2001-07-31 | — | — | US | disclosed |
| US-6090394-A | FOR HUMANS, ANIMALS | PFIZER INC. (US) | 2000-07-18 | — | — | US | disclosed |
| US-6075043-A | Parasiticidal pyrazoles | PFIZER INC. (US) | 2000-06-13 | — | — | US | disclosed |
| US-6019986-A | Parasiticidal pyrazoles | PFIZER INC. (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0946515-A1 | PARASITICIDAL PYRAZOLES | Pfizer Limited (GB) | 1999-10-06 | — | — | EP | disclosed |
| EP-0933363-A1 | Parasiticidal pyrazoles | Pfizer Limited (GB) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998024767-A1 | PARASITICIDAL PYRAZOLES | PFIZER LIMITED (GB) | 1998-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137524-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP4X1, EPX, CYP2C9 | L3MBTL1 1016/4885POLB 3174/4885GAA 1424/4885 |
| US-20110196011-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP4X1, EPX, CYP2C9 | L3MBTL1 1016/4885POLB 3174/4885GAA 1424/4885 |
| US-20020173662-A1 | Parasiticidal pyrazoles | HRH3, HRH2, HRH1 | L3MBTL1 953/4885POLB 4325/4885GAA 3178/4885 |
| US-20090312371-A1 | SUBSTITUTED ARYLPYRAZOLES | CYP3A43, CYP3A4, CYP4X1 | L3MBTL1 1465/4885POLB 2859/4885GAA 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.