Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1051150 | 0.86 | REN (0.45) | RENADORA2AADORA2BKMOGLS | |
| SCHEMBL13131423 | 0.85 | ADORA2A (0.44) | RENADORA2AADORA2BKMOGLS | |
| SCHEMBL13132264 | 0.83 | REN (0.46) | RENADORA2AADORA2BKMOGLS | |
| SCHEMBL78153 | 0.83 | REN (0.55) | RENADORA2AADORA2BKMOGLS | |
| SCHEMBL4249553 | 0.82 | REN (0.45) | RENADORA2AADORA2BKMOGLS | |
| SCHEMBL13448565 | 0.82 | REN (0.45) | RENADORA2AADORA2BKMOGLS | |
| SCHEMBL4256101 | 0.82 | GLS (0.62) | RENGLSMEN1KMT2AALDH1A1 | |
| SCHEMBL2807350 | 0.80 | REN (0.48) | RENKMOHTTSLC22A12KMT2A | |
| SCHEMBL14752740 | 0.79 | ADORA2A (0.44) | ADORA2AADORA2BKMOGLSSLC22A12 | |
| SCHEMBL4736285 | 0.79 | REN (0.44) | RENADORA2AADORA2BKMOGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |