Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 6/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | HTR1A | P08908 | 5/20 | 0.48 |
| ▸ | HTR2A | P28223 | 5/20 | 0.48 |
| ▸ | HTR7 | P34969 | 5/20 | 0.48 |
| ▸ | HTR6 | P50406 | 5/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 5/20 | 0.48 |
| ▸ | CA12 | O43570 | 4/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667679 | 0.89 | DRD2 (0.48) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL8047953 | 0.85 | ADRA1D (0.40) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8667643 | 0.83 | CA9 (0.51) | ADRA1DADRA1AADRA1BDRD2DRD4 | |
| SCHEMBL8667503 | 0.83 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8670252 | 0.80 | ADRA1D (0.53) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8047935 | 0.80 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL6324557 | 0.80 | CA9 (0.73) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL9480365 | 0.80 | GAA (0.47) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL8671286 | 0.79 | HDAC1 (0.55) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL9400876 | 0.79 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BDRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633260-B1 | 2,3-Dihydro-1,4-benzodioxan-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INT RES (NL) | 2001-11-07 | — | — | EP | disclosed |
| US-6096763-A | ADMINISTERING TO THE PATIENTS A2-OXO-1-BENZIMIDAZOLINYL)PIPERIDIN-1-YL)ALKYL)-1,2BENZISOTHIA ZOL-3-(2H)-ONE DERIVATIVE AS ALPHA-1A ADRENERGIC RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 2000-08-01 | — | — | US | disclosed |
| US-5952351-A | DERIVATIVES OF 1,1,3-TRIOXO-2-((2-OXOBENZIMIDAZOLIN- OR BENZOXAZOLIN-2-YL)-PIPERIDIN-4,1-YLENE-)-1,2-BENZISOTHIAZOLE; TREATMENT OF BENIGN PROSTATIC HYPERPLASIA; SELECTIVE RELAXATION OF SMOOTH MUSCLE WITHOUT INDUCING HYPOTENSION | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5807856-A | Alpha 1a adrenergic receptor antagonist | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |
| US-5760054-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0755392-A4 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1997-05-02 | — | — | EP | disclosed |
| EP-0755392-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1996025934-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | disclosed |
| US-5462942-A | 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT 1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| WO-1995028397-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-10-26 | — | — | WO | disclosed |
| EP-0633260-A1 | 2,3-Dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-01-11 | — | — | EP | disclosed |
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |
| US-5187276-A | Anxiolytics, neuroleptics, antidepressants, and nootropic agents | TROPONWERKE GMBH & CO. KG. (DE) | 1993-02-16 | — | — | US | disclosed |
| US-4988809-A | CENTRAL NERVOUS SYSTEM | TROPONWERKE GMBH & CO., KG (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |
| US-4818756-A | CENTRAL NERVOUS SYSTEM DISORDERS | TROPONWERKE GMBH & CO., KG (DE) | 1989-04-04 | — | — | US | disclosed |