Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 8/20 | 0.47 |
| ▸ | CA12 | O43570 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667503 | 0.96 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL8667501 | 0.81 | ADRA1D (0.39) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL8973563 | 0.79 | CA9 (0.72) | CA9CA12HPGDCA2HTR1A | |
| SCHEMBL7815416 | 0.79 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL8667643 | 0.79 | CA9 (0.51) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL8670252 | 0.76 | ADRA1D (0.53) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL8047945 | 0.76 | CA9 (0.42) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL8671286 | 0.75 | HDAC1 (0.55) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL6324557 | 0.75 | CA9 (0.73) | ADRA1DADRA1AADRA1BCA9CA12 | |
| SCHEMBL8047906 | 0.74 | CA9 (0.49) | ADRA1DADRA1AADRA1BCA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |
| US-5187276-A | Anxiolytics, neuroleptics, antidepressants, and nootropic agents | TROPONWERKE GMBH & CO. KG. (DE) | 1993-02-16 | — | — | US | disclosed |
| US-4988809-A | CENTRAL NERVOUS SYSTEM | TROPONWERKE GMBH & CO., KG (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |