Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670390 | 0.90 | HDAC1 (0.53) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8047906 | 0.88 | CA9 (0.49) | ADRA1DADRA1AADRA1BL3MBTL1DRD2 | |
| SCHEMBL8670248 | 0.86 | L3MBTL1 (0.44) | ADRA1DADRA1AADRA1BL3MBTL1DRD2 | |
| SCHEMBL8047945 | 0.84 | CA9 (0.42) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8667643 | 0.83 | CA9 (0.51) | ADRA1DADRA1AADRA1BDRD2CA12 | |
| SCHEMBL8667503 | 0.80 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL7815416 | 0.80 | ADRA1D (0.51) | ADRA1DADRA1AADRA1BDRD2HTR1A | |
| SCHEMBL8670388 | 0.79 | HDAC1 (0.46) | ADRA1DADRA1AADRA1BL3MBTL1DRD2 | |
| SCHEMBL9400998 | 0.77 | CA12 (0.49) | L3MBTL1DRD2HTR1AHTR2AHTR7 | |
| SCHEMBL6324557 | 0.76 | CA9 (0.73) | ADRA1DADRA1AADRA1BDRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760054-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0755392-A4 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1997-05-02 | — | — | EP | disclosed |
| EP-0755392-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028397-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-10-26 | — | — | WO | disclosed |