Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18621847 | 0.89 | FFAR1 (0.48) | ACMSDFFAR1PTPN5TDP1BACE1 | |
| SCHEMBL25496067 | 0.86 | CYP4F2 (0.47) | ACMSDMAP4K4FFAR1PRKCIPTPN5 | |
| SCHEMBL1520795 | 0.85 | PRKCI (0.61) | ACMSDFFAR1CDK8PRKCIPTPN5 | |
| SCHEMBL5865105 | 0.84 | TDP1 (0.62) | ACMSDMAP4K4FFAR1CDK8PRKCI | |
| SCHEMBL18069884 | 0.81 | AGXT (0.57) | ACMSDMAP4K4CDK8PRKCIPTPN5 | |
| SCHEMBL2571534 | 0.81 | TAAR1 (0.55) | ACMSDMAP4K4CDK8PRKCITDP1 | |
| SCHEMBL7248747 | 0.81 | ACMSD (0.54) | ACMSDMAP4K4CDK8PRKCICYP4F2 | |
| SCHEMBL7247547 | 0.81 | ACMSD (0.50) | ACMSDMAP4K4CDK8PRKCICYP4F2 | |
| SCHEMBL15725304 | 0.80 | CA2 (0.52) | CYP4F2CYP4A11TDP1BACE1 | |
| SCHEMBL30671117 | 0.80 | FFAR1 (0.71) | FFAR1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144415-A2 | FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000042045-A2 | FUNCTIONALIZED HETEROCYCLES AS CHEMOKINE RECEPTOR MODULATORS | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |