Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11418157 | 0.74 | CFTR (0.46) | CFTRALDH1A1MAPTGAAALPG | |
| SCHEMBL14246552 | 0.70 | NPC1 (0.42) | NPC1ADAM17CFTRALDH1A1MAPT | |
| SCHEMBL7058663 | 0.69 | CFTR (0.42) | CFTRALDH1A1MAPTGAAALPG | |
| SCHEMBL7058667 | 0.69 | AOX1 (0.53) | CFTRALDH1A1MAPTGAAALPG | |
| SCHEMBL6572723 | 0.69 | CFTR (0.44) | CFTRALDH1A1MAPTGAAALPG | |
| SCHEMBL28979738 | 0.68 | ALDH1A1 (0.53) | CFTRALDH1A1MAPTGAAALPG | |
| SCHEMBL6894560 | 0.68 | CFTR (0.45) | CFTRALDH1A1MAPTGAAALPG | |
| SCHEMBL264237 | 0.67 | CNR1 (0.46) | CYP3A4CYP2C19CYP1A2ALDH1A1ALOX12 | |
| SCHEMBL7364597 | 0.67 | ALDH1A1 (0.48) | CFTRALDH1A1MAPTGAAALPG | |
| SCHEMBL27877604 | 0.67 | CFTR (0.43) | CFTRALDH1A1MAPTGAAALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0716856-B1 | Therapeutic uses of 2',5'-oligoadenylate derivatives | UNIV TEMPLE (US) | 2001-08-29 | — | — | EP | disclosed |
| EP-0420872-B1 | THERAPEUTIC USES OF 2',5'-OLIGOADENYLATE DERIVATIVES | UNIV TEMPLE (US) | 1996-08-28 | — | — | EP | disclosed |
| EP-0716856-A2 | Therapeutic uses of 2',5'-oligoadenylate derivatives | Temple University of the Commonwealth System of Higher Education (US) | 1996-06-19 | — | — | EP | disclosed |
| EP-0420872-A4 | THERAPEUTIC USES OF 2',5'-OLIGOADENYLATE DERIVATIVES | — | 1992-10-21 | — | — | EP | disclosed |
| EP-0420872-A1 | THERAPEUTIC USES OF 2',5'-OLIGOADENYLATE DERIVATIVES. | UNIV TEMPLE (US) | 1991-04-10 | — | — | EP | disclosed |