Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | CTSL | P07711 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | LARS1 | Q9P2J5 | 5/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611850 | 0.84 | CTSL (0.42) | CTSKCTSLSCN9ACTSBCTSS | |
| SCHEMBL7611845 | 0.84 | CTSL (0.42) | CTSKCTSLSCN9ACTSBCTSS | |
| SCHEMBL7830243 | 0.81 | CTSK (0.39) | CTSKCTSLSCN9ACTSBCTSS | |
| Trifluoroacetic Acid SCHEMBL7611852 | 0.79 | CTSL (0.45) | CTSKCTSLCTSBCTSSLARS1 | |
| SCHEMBL7611319 | 0.76 | CTSL (0.45) | CTSKCTSLCTSBCTSSLARS1 | |
| SCHEMBL7819471 | 0.75 | REN (0.47) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6623377 | 0.75 | CTSL (0.47) | CTSKCTSLCTSBCTSSLARS1 | |
| SCHEMBL27513601 | 0.73 | CTSL (0.42) | CTSKCTSLCTSBCTSSLARS1 | |
| SCHEMBL7813672 | 0.71 | HSPA5 (0.49) | CTSKCTSLSCN9ACTSBCTSS | |
| SCHEMBL6659791 | 0.70 | CTSL (0.47) | CTSKCTSLCTSBCTSSFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068304-A4 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORP (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1068304-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999053039-A1 | TREATMENT OF PARASITIC DISEASES BY INHIBITION OF CYSTEINE PROTEASES OF THE PAPAIN SUPERFAMILY | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |