Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.30 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813650 | 0.69 | CYP11B2 (0.31) | — | |
| SCHEMBL7814352 | 0.69 | HCAR1 (0.34) | — | |
| SCHEMBL11923731 | 0.62 | DPP4 (0.41) | — | |
| SCHEMBL12263310 | 0.62 | MEN1 (0.43) | — | |
| SCHEMBL28230824 | 0.62 | TLR8 (0.43) | TLR7 | |
| SCHEMBL7817046 | 0.62 | POLB (0.33) | — | |
| SCHEMBL7813559 | 0.59 | TLR8 (0.41) | — | |
| SCHEMBL24401836 | 0.58 | KDM4E (0.32) | TLR7 | |
| SCHEMBL12362580 | 0.58 | HSP90AB1 (0.49) | TLR7 | |
| SCHEMBL29924487 | 0.57 | TYR (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091941-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2001-04-18 | — | — | EP | claimed |
| WO-2000001675-A1 | NOVEL BENZIMIDAZOLES AS CORTICOTROPIN RELEASE FACTOR ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-01-13 | — | — | WO | claimed |