Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304293 | 0.81 | DRD2 (0.70) | HTR1ADRD2 | |
| SCHEMBL7815594 | 0.81 | SLC6A4 (0.46) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7814691 | 0.75 | SIGMAR1 (0.43) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL28784019 | 0.74 | HTR1A (0.51) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL8545434 | 0.73 | DRD2 (0.40) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7521522 | 0.73 | ALDH1A1 (0.63) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL8547387 | 0.73 | HTR1A (0.42) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL2114371 | 0.72 | DRD2 (0.55) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL9378687 | 0.72 | DRD3 (0.64) | HTR1ADRD2DRD3SIGMAR1SLC6A4 | |
| SCHEMBL9232873 | 0.72 | HRH3 (0.59) | ADRA1DADRA1AADRA1BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| CN-1064356-C | New Piperazine, piperidine and 1,2,5,6-tetrahydropyridine compounds, process for preparation thereof and pharmaceutical compositions containing them | ADIR (FR) | 2001-04-11 | — | — | CN | disclosed |
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |
| CN-1142494-A | New Piperazine, piperidine and 1,2,5,6-tetrahydropyridine compounds, process for preparation thereof and pharmaceutical compositions containing them | ADIR (FR) | 1997-02-12 | — | — | CN | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |