Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828601 | 0.88 | PARP1 (0.37) | LMNAKDM4EHSD17B10PARP1ALDH1A1 | |
| SCHEMBL7823570 | 0.80 | PARP1 (0.38) | LMNAPARP1ALDH1A1CYP2C9CYP3A4 | |
| SCHEMBL7822908 | 0.79 | KDM4E (0.38) | LMNAKDM4EHSD17B10PARP1ALDH1A1 | |
| SCHEMBL7824009 | 0.79 | PARP1 (0.46) | LMNAKDM4EHSD17B10PARP1ALDH1A1 | |
| SCHEMBL7815301 | 0.78 | KDM4E (0.42) | KDM4EPARP1ALDH1A1MEN1KMT2A | |
| SCHEMBL7825628 | 0.78 | PTGES (0.46) | KDM4EALDH1A1CYP2C9MEN1KMT2A | |
| SCHEMBL7831864 | 0.76 | KDM4E (0.40) | KDM4EHSD17B10ALDH1A1CYP2C9PTGES | |
| SCHEMBL7826505 | 0.76 | PTGES (0.47) | HSD17B10PARP1ALDH1A1CYP2C9MEN1 | |
| SCHEMBL8057842 | 0.75 | KDM4E (0.35) | LMNAKDM4EHSD17B10PARP1ALDH1A1 | |
| SCHEMBL7826265 | 0.75 | CSNK2A1 (0.41) | KDM4EPARP1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |