Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.38 |
| ▸ | ABAT | P80404 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753579 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TDP1TAS1R3TAS1R1TSHR | |
| SCHEMBL38133 | 0.82 | ALDH1A1 (0.58) | ALDH1A1TDP1TAS1R3TAS1R1TSHR | |
| SCHEMBL3628542 | 0.80 | ALDH1A1 (0.55) | ALDH1A1TDP1TAS1R3TAS1R1TSHR | |
| SCHEMBL16536 | 0.80 | ALDH1A1 (0.62) | ALDH1A1TDP1TSHRKMT2AGLA | |
| SCHEMBL23391004 | 0.78 | ALDH1A1 (0.52) | ALDH1A1TDP1TAS1R3TAS1R1TSHR | |
| SCHEMBL273504 | 0.78 | ALDH1A1 (0.52) | ALDH1A1TDP1TAS1R3TAS1R1KMT2A | |
| SCHEMBL8490138 | 0.78 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRKMT2AGLA | |
| SCHEMBL4344885 | 0.78 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRKMT2AGLA | |
| SCHEMBL11050679 | 0.78 | ALDH1A1 (0.60) | ALDH1A1TDP1TSHRKMT2AGLA | |
| SCHEMBL362842 | 0.78 | ALDH1A1 (0.52) | ALDH1A1TDP1TAS1R3TAS1R1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | claimed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | claimed |
| EP-2228376-B1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | KITASATO INST (JP) | 2015-06-03 | — | — | EP | disclosed |
| US-8759560-B2 | Surface-modified zirconia nanocrystal particle and method for producing same | HOYA CORPORATION (JP) | 2014-06-24 | — | — | US | disclosed |
| US-8519128-B2 | Pyripyropene derivatives having an ACAT2-inhibiting activity | THE KITASATO INSTITUTE (JP) | 2013-08-27 | — | — | US | disclosed |
| US-20120071680-A1 | SURFACE-MODIFIED ZIRCONIA NANOCRYSTAL PARTICLE AND METHOD FOR PRODUCING SAME | HOYA CORPORATION (JP) | 2012-03-22 | — | — | US | disclosed |
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | THE KITASATO INSTITUTE (JP) | 2011-07-28 | — | — | US | disclosed |
| EP-2228376-A1 | PYRIPYROPENE DERIVATIVE HAVING ACAT2-INHIBITING ACTIVITY | The Kitasato Institute (JP) | 2010-09-15 | — | — | EP | disclosed |
| US-20090318663-A1 | Polymerizable Spherical Transition Metal Complex, Spherical Transition Metal Complex, and Production Method Thereof | UNIVERSITY OF TOKYO, THE (JP) | 2009-12-24 | — | — | US | disclosed |
| US-4042538-A | Sugar p-vinylbenzoyl ester and copolymers thereof | TATE & LYLE LIMITED (EN) | 1977-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184173-A1 | Pyripyropene Derivatives Having An ACAT2-Inhibiting Activity | ACAT2, ACAT1, AGPAT2 | ALDH1A1 1202/4885TDP1 1436/4885TAS1R3 3614/4885 |
| US-20120071680-A1 | SURFACE-MODIFIED ZIRCONIA NANOCRYSTAL PARTICLE AND METHOD FOR PRODUCING SAME | PIM1, NOXO1, PIM3 | ALDH1A1 2682/4885TDP1 2914/4885TAS1R3 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.