Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.33 |
| ▸ | CHRNG | P07510 | 3/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.33 |
| ▸ | CHRND | Q07001 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.33 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL25328842 | 0.97 | EPHX2 (0.37) | EPHX2LMNABLMCHRNB2CHRNB4 | |
| SCHEMBL18973534 | 0.90 | EPHX2 (0.34) | EPHX2LMNABLM | |
| SCHEMBL16748090 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL31716940 | 0.81 | EPHX2 (0.32) | EPHX2LMNACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL31575750 | 0.78 | ALDH1A1 (0.44) | LMNACHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL2596586 | 0.78 | ESR2 (0.38) | LMNACHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL5044295 | 0.78 | ESR2 (0.38) | LMNACHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL11509613 | 0.78 | CHRNB2 (0.36) | LMNACHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL2596585 | 0.78 | ESR2 (0.38) | LMNACHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL25050066 | 0.77 | KDM1A (0.31) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472956-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE | Bristol-Myers Squibb Company (US) | 2024-12-11 | — | — | EP | disclosed |
| US-12162848-B2 | Inhibitors of protein tyrosine phosphatase, compositions, and methods of use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-12-10 | — | — | US | disclosed |
| US-11992494-B2 | Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-05-28 | — | — | US | disclosed |
| US-11826351-B2 | Compounds useful as kinase inhibitors | LOXO ONCOLOGY INC. (US) | 2023-11-28 | — | — | US | disclosed |
| US-20230372298-A1 | COMPOUNDS USEFUL AS KINASE INHIBITORS | LOXO ONCOLOGY, INC. | 2023-11-23 | — | — | US | disclosed |
| EP-2970176-B1 | MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO | CORTEVA AGRISCIENCE LLC (US) | 2023-10-25 | — | — | EP | disclosed |
| US-20230322695-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE | BRISTOL-MYERS SQUIBB COMPANY | 2023-10-12 | — | — | US | disclosed |
| US-20230322695-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE | BRISTOL-MYERS SQUIBB COMPANY | 2023-10-12 | — | — | US | disclosed |
| US-20230322695-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE | BRISTOL-MYERS SQUIBB COMPANY | 2023-10-12 | — | — | US | disclosed |
| WO-2023147531-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-03 | — | — | WO | disclosed |
| US-20070293541-A1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2007-12-20 | — | — | US | disclosed |
| US-20070293541-A1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2007-12-20 | — | — | US | disclosed |
| US-7282516-B2 | 4-cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof | SANOFI-AVENTIS (FR) | 2007-10-16 | — | — | US | disclosed |
| US-7282516-B2 | 4-cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof | SANOFI-AVENTIS (FR) | 2007-10-16 | — | — | US | disclosed |
| US-20070149596-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2007-06-28 | — | — | US | disclosed |
| US-20070149596-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2007-06-28 | — | — | US | disclosed |
| EP-0652871-B1 | BENZODIAZEPINE DERIVATIVES | MERCK SHARP & DOHME (GB) | 2001-10-17 | — | — | EP | disclosed |
| US-5618812-A | GASTRIN ANTAGONISTS; GASTROINTESTINAL DISORDERS | MERCK SHARP & DOHME, LTD. (GB) | 1997-04-08 | — | — | US | disclosed |
| EP-0652871-A1 | BENZODIAZEPINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-05-17 | — | — | EP | disclosed |
| WO-1994003437-A1 | BENZODIAZEPINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322695-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE | PTPN2, PTPN22, PTPN5 | EPHX2 1784/4885LMNA 4590/4885BLM 2909/4885 |
| US-11992494-B2 | Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists | PTAFR, PDGFRA, PDGFRB | EPHX2 1805/4885LMNA 4583/4885BLM 4591/4885 |
| US-11826351-B2 | Compounds useful as kinase inhibitors | BTK, ABL1, LCK | EPHX2 3195/4885LMNA 4225/4885BLM 1605/4885 |
| US-12162848-B2 | Inhibitors of protein tyrosine phosphatase, compositions, and methods of use | PTPN2, PTPN22, PTPN5 | EPHX2 1784/4885LMNA 4590/4885BLM 2909/4885 |
| US-20070293541-A1 | 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF | CBR3, CNR1, CNR2 | EPHX2 2153/4885LMNA 2672/4885BLM 4181/4885 |
| US-20230372298-A1 | COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, ABL1, LCK | EPHX2 3195/4885LMNA 4225/4885BLM 1605/4885 |
| US-20070149596-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | PYCR1, PRMT9, PRLHR | EPHX2 1157/4885LMNA 3748/4885BLM 3957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.