SCHEMBL7818477

SCHEMBL7818477

c1ccc(CCCSc2nsnc2C2CN3CCC2CC3)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.58
CHRM1 P11229 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7810578 0.95 CHRM2 (0.64) CHRM2CHRM1
Fumaric Acid SCHEMBL7820915 0.92 CHRM2 (0.51) CHRM2CHRM1
Oxalic Acid SCHEMBL7819179 0.91 CHRM2 (0.58) CHRM2CHRM1
SCHEMBL7810907 0.89 CHRM2 (0.65) CHRM2CHRM1
SCHEMBL8195856 0.85 CHRM1 (0.54) CHRM1
Oxalic Acid SCHEMBL7811971 0.85 CHRM2 (0.61) CHRM2CHRM1
SCHEMBL8202813 0.84 CHRM2 (0.57) CHRM2
Hydrochloric Acid SCHEMBL8200001 0.84 CHRM1 (0.53) CHRM1
SCHEMBL7818023 0.84 CHRM2 (0.48) CHRM2
SCHEMBL8188383 0.81 CHRM2 (0.59) CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6281233-B1 AZABICYCLIC RING-SUBSTITUTED THIA- OR OXADIAZOLES NOVO NORDISK A/S (DK) 2001-08-28 US claimed
EP-0714394-B1 ANTIPSYCHOTIC METHOD WITH THIADIAZOLE AND OXADIAZOLE DERIVATIVES NOVO NORDISK AS (DK) 2001-06-20 EP claimed
EP-0544779-B1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK AS (DK) 1998-12-02 EP claimed
EP-0873124-A1 A METHOD OF TREATING HYPERCHOLESTEROLEMIA AND RELATED DISORDERS NOVO NORDISK A/S (DK) 1998-10-28 EP claimed
EP-0866702-A1 METHOD FOR TREATING PAIN ELI LILLY AND COMPANY (US) 1998-09-30 EP claimed
WO-1997020556-A9 METHOD FOR TREATING PAIN 1997-10-02 WO claimed
WO-1997025043-A1 A METHOD OF TREATING HYPERCHOLESTEROLEMIA AND RELATED DISORDERS NOVO NORDISK A/S (DK) 1997-07-17 WO claimed
WO-1997020556-A1 METHOD FOR TREATING PAIN ELI LILLY AND COMPANY (US) 1997-06-12 WO claimed
EP-0714394-A1 ANTIPSYCHOTIC METHOD NOVO NORDISK A/S (DK) 1996-06-05 EP claimed
WO-1996014316-A1 A METHOD OF TREATING URINARY BLADDER DYSFUNCTIONS NOVO NORDISK A/S (DK) 1996-05-17 WO claimed
WO-1995005379-A1 ANTIPSYCHOTIC METHOD NOVO NORDISK A/S (DK) 1995-02-23 WO claimed
US-20090209510-A1 Novel Method of Treating Hyperlipidemia TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-08-20 US disclosed
US-20090209510-A1 Novel Method of Treating Hyperlipidemia TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-08-20 US disclosed
US-20090118255-A1 Crp Lowering Agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-05-07 US disclosed
US-20090118255-A1 Crp Lowering Agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-05-07 US disclosed
EP-0873124-A1 A METHOD OF TREATING HYPERCHOLESTEROLEMIA AND RELATED DISORDERS NOVO NORDISK A/S (DK) 1998-10-28 EP disclosed
WO-1997025043-A1 A METHOD OF TREATING HYPERCHOLESTEROLEMIA AND RELATED DISORDERS NOVO NORDISK A/S (DK) 1997-07-17 WO disclosed
WO-1996013166-A1 METHOD FOR TREATING ANXIETY ELI LILLY AND COMPANY (US) 1996-05-09 WO disclosed
EP-0709093-A2 Method for treating anxiety using an azabicyclic oxadiazole or thiadiazole compound ELI LILLY AND COMPANY (US) 1996-05-01 EP disclosed
US-5484794-A THIA- OR OXA-DIAZOLE COMPOUNDS ELI LILLY AND COMPANY (US) 1996-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090118255-A1 Crp Lowering Agent SPR, RBP1, HMGCR CHRM2 3365/4885CHRM1 3495/4885
US-20090209510-A1 Novel Method of Treating Hyperlipidemia HMGCR, LIPC, LIPA CHRM2 3568/4885CHRM1 4124/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.