Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7818422 | 0.95 | ALDH1A1 (0.39) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL1387871 | 0.81 | NPC1 (0.38) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL9056690 | 0.80 | KDM4E (0.44) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL30284405 | 0.80 | KDM4E (0.50) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL361847 | 0.80 | KDM4E (0.50) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL1387642 | 0.77 | ALDH1A1 (0.40) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL2517095 | 0.76 | KDM4E (0.45) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL9104399 | 0.74 | KDM4E (0.40) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL16275873 | 0.73 | SMN1; SMN2 (0.37) | KDM4EMAPTALDH1A1LMNAGAA | |
| SCHEMBL13220106 | 0.73 | HTT (0.39) | KDM4EMAPTALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0704067-B1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG IND OHIO INC (US) | 2001-08-01 | — | — | EP | disclosed |
| EP-0704067-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0704067-A4 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES INC (US) | 1996-02-02 | — | — | EP | disclosed |
| US-5458815-A | Photochromic naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |
| US-5384077-A | Naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 1995-01-24 | — | — | US | disclosed |
| WO-1995000866-A1 | PHOTOCHROMIC NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-01-05 | — | — | WO | disclosed |