Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 7/20 | 0.42 |
| ▸ | EP300 | Q09472 | 9/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7826567 | 0.99 | MAPT (0.45) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL29502920 | 0.83 | MAPT (0.59) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL7824722 | 0.79 | KDM4E (0.61) | MAPTALDH1A1LMNAHPGDKMT2A | |
| Hydrochloric Acid SCHEMBL7812760 | 0.77 | MAPT (0.64) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL7821022 | 0.76 | MAPT (0.65) | MAPTALDH1A1LMNAHPGDKMT2A | |
| Hydrochloric Acid SCHEMBL7826957 | 0.75 | CYP3A4 (0.68) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL13349142 | 0.74 | MAPT (0.46) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL7820317 | 0.71 | ALDH1A1 (0.47) | MAPTALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL10132560 | 0.69 | BAD (0.76) | MAPTALDH1A1LMNAHPGDKMT2A | |
| Bromide SCHEMBL11728626 | 0.69 | IDO1 (0.44) | MAPTALDH1A1LMNAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888346-B1 | CORALYNE ANALOGS AS TOPOISOMERASE INHIBITORS | UNIV RUTGERS (US) | 2001-06-06 | — | — | EP | claimed |