Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775243 | 0.84 | ENPP2 (0.42) | ENPP2KDM4EALDH1A1MGLLHSD17B1 | |
| SCHEMBL23531983 | 0.79 | BTK (0.41) | ENPP2KDM4EALDH1A1MGLL | |
| SCHEMBL150235 | 0.77 | ALDH1A1 (0.54) | ENPP2KDM4EALDH1A1MGLLLPL | |
| Hydrochloric Acid SCHEMBL27945132 | 0.77 | PARP1 (0.47) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL25751951 | 0.77 | SIGMAR1 (0.58) | KDM4ESIGMAR1HSD17B1HSD17B2SCN2A | |
| SCHEMBL8884787 | 0.77 | SIGMAR1 (0.50) | ALDH1A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL214884 | 0.77 | ALDH1A1 (0.59) | KDM4EALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL30203518 | 0.76 | BRD4 (0.49) | ENPP2KDM4EALDH1A1MGLLHSD17B1 | |
| SCHEMBL27194900 | 0.76 | BRD4 (0.49) | ENPP2KDM4EALDH1A1MGLLHSD17B1 | |
| Hydrochloric Acid SCHEMBL9098386 | 0.76 | ALDH1A1 (0.52) | ENPP2KDM4EALDH1A1MGLLLPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149093-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| US-6307056-B1 | INHIBIT OR MODULATE PROTEIN KINASES, IN PARTICULAR JNK PROTEIN KINASES. | HOFFMAN-LA ROCHE INC. | 2001-10-23 | — | — | US | disclosed |
| WO-2000035909-A1 | 4-ARYLOXINDOLES AS INHIBITORS OF JNK PROTEIN KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |