Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820160 | 0.84 | ENPP2 (0.44) | ENPP2KDM4EALDH1A1MGLLHSD17B1 | |
| SCHEMBL23531983 | 0.80 | BTK (0.41) | ENPP2KDM4EALDH1A1MGLL | |
| SCHEMBL150235 | 0.79 | ALDH1A1 (0.54) | ENPP2KDM4EALDH1A1MGLLCA4 | |
| SCHEMBL12266129 | 0.79 | SMN1; SMN2 (0.50) | ENPP2ALDH1A1 | |
| SCHEMBL7858429 | 0.78 | CES2 (0.44) | KDM4EALDH1A1BRD4LIN28APDK2 | |
| SCHEMBL27194900 | 0.78 | BRD4 (0.49) | ENPP2KDM4EALDH1A1MGLLBRD4 | |
| SCHEMBL30203518 | 0.78 | BRD4 (0.49) | ENPP2KDM4EALDH1A1MGLLBRD4 | |
| SCHEMBL11409410 | 0.77 | ALDH1A1 (0.52) | KDM4EALDH1A1BRD4LIN28APDK2 | |
| Hydrochloric Acid SCHEMBL9098386 | 0.77 | ALDH1A1 (0.52) | ENPP2KDM4EALDH1A1MGLLCA4 | |
| SCHEMBL29674755 | 0.76 | HSD17B1 (0.57) | KDM4EALDH1A1BRD4LIN28AHSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058351-A1 | Deuterated pyrazolo(1,5-a)pyrimidine compounds; sedative or hypnotic agents; sleep disorders such as insomnia; modulating a GABA receptor-chloride ionophore complex in a cell through binding to the neurosteroid site on the complex | CONCERT PHARMACEUTICALS INC. (US) | 2008-03-06 | — | — | US | disclosed |
| WO-2008005471-A2 | NOVEL HETEROBICYCLIC COMPOUNDS | CONCERT PHARMACEUTICALS INC. (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058351-A1 | Deuterated pyrazolo(1,5-a)pyrimidine compounds; sedative or hypnotic agents; sleep disorders such as insomnia; modulating a GABA receptor-chloride ionophore complex in a cell through binding to the neurosteroid site on the complex | GABRA5, GABRA1, GABRA4 | ENPP2 3888/4885KDM4E 2844/4885ALDH1A1 1696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.