Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821489 | 0.83 | HTR1A (0.46) | HTR1ADRD2 | |
| SCHEMBL7818467 | 0.81 | HTR1A (0.47) | HTR1AALDH1A1DRD2 | |
| SCHEMBL31052148 | 0.77 | HTR1A (0.52) | HTR1AALDH1A1DRD2 | |
| SCHEMBL7818017 | 0.75 | HTR1A (0.59) | HTR1ADRD2 | |
| SCHEMBL7808218 | 0.74 | DRD2 (0.43) | HTR1ADRD2 | |
| SCHEMBL31051992 | 0.73 | HTR1A (0.50) | HTR1AALDH1A1DRD2 | |
| SCHEMBL7821041 | 0.73 | KDM4E (0.36) | HTR1AALDH1A1DRD2 | |
| SCHEMBL7807803 | 0.72 | HTR1A (0.62) | HTR1ADRD2 | |
| SCHEMBL1455855 | 0.72 | ADRB1 (0.59) | HTR1ADRD2 | |
| SCHEMBL31051799 | 0.72 | HTR1A (0.52) | HTR1AALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633260-B1 | 2,3-Dihydro-1,4-benzodioxan-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INT RES (NL) | 2001-11-07 | — | — | EP | disclosed |
| US-5462942-A | 2,3-dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT 1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| EP-0633260-A1 | 2,3-Dihydro-1,4-benzodioxin-5-yl-piperazine derivatives having 5-HT1A-antagonistic activity | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1995-01-11 | — | — | EP | disclosed |