Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809569 | 0.77 | PKM (0.52) | PKMNPSR1ALDH1A1GAAUSP2 | |
| SCHEMBL23271634 | 0.76 | PKM (0.54) | PKMNPSR1ALDH1A1GAAUSP2 | |
| SCHEMBL7821180 | 0.76 | PKM (0.54) | PKMNPSR1ALDH1A1GAAHPGD | |
| SCHEMBL7676239 | 0.76 | NPSR1 (0.56) | PKMNPSR1ALDH1A1GAAUSP2 | |
| SCHEMBL7901310 | 0.75 | KMT2A (0.60) | PKMNPSR1ALDH1A1GAAUSP2 | |
| SCHEMBL14234223 | 0.75 | PKM (0.51) | PKMNPSR1ALDH1A1GAAUSP2 | |
| SCHEMBL16592104 | 0.75 | NPSR1 (0.55) | PKMNPSR1ALDH1A1GAAMAPK1 | |
| SCHEMBL14234225 | 0.74 | PKM (0.53) | PKMNPSR1ALDH1A1GAAUSP2 | |
| SCHEMBL27716277 | 0.74 | AGBL2 (0.69) | NPSR1ALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL8788592 | 0.73 | KMT2A (0.55) | PKMNPSR1ALDH1A1GAAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024759-A2 | IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE PY+3 BINDING SITE OF TYROSENE KINASE P56 LCK SH2 DOMAIN | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2008-02-28 | — | — | WO | disclosed |
| US-20070196395-A1 | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-08-23 | — | — | US | disclosed |
| US-20070196395-A1 | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-08-23 | — | — | US | disclosed |
| US-20070099970-A1 | Immunomodulatory compounds that target and inhibit the pY'binding site of tyrosene kinase p56 LCK SH2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-05-03 | — | — | US | disclosed |
| US-20070099970-A1 | Immunomodulatory compounds that target and inhibit the pY'binding site of tyrosene kinase p56 LCK SH2 domain | UNIVERSITY OF MARYLAND, BALTIMORE | 2007-05-03 | — | — | US | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099970-A1 | Immunomodulatory compounds that target and inhibit the pY'binding site of tyrosene kinase p56 LCK SH2 domain | LCK, PTPN6, PTPN22 | PKM 2857/4885NPSR1 2382/4885ALDH1A1 4878/4885 |
| US-20070196395-A1 | Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain | LCK, PTPN6, PTPN22 | PKM 2857/4885NPSR1 2382/4885ALDH1A1 4878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.