Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.46 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7821353 | 1.00 | PHLPP2 (0.57) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 | |
| SCHEMBL8843743 | 0.81 | PHLPP2 (0.75) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 | |
| SCHEMBL8843749 | 0.81 | PHLPP2 (0.75) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 | |
| SCHEMBL16153076 | 0.81 | MEN1 (0.64) | RPS6KA3MEN1HSP90AA1KMT2AATM | |
| SCHEMBL7813050 | 0.79 | RPS6KA3 (0.63) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 | |
| SCHEMBL7813054 | 0.79 | RPS6KA3 (0.63) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 | |
| SCHEMBL5359392 | 0.79 | RPS6KA3 (0.56) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 | |
| SCHEMBL4808253 | 0.79 | LMNA (0.74) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 | |
| SCHEMBL2171353 | 0.79 | LMNA (0.74) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 | |
| SCHEMBL28560987 | 0.78 | POLB (0.83) | PHLPP2POLBCYP2D6RPS6KA3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-03-06 | — | — | US | disclosed |
| EP-2677865-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | Icahn School of Medicine at Mount Sinai (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012116170-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | ZHOU MING-MING (US) | 2012-08-30 | — | — | WO | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | NFKBIA, NFKB2, IKBKG | PHLPP2 1158/4885POLB 96/4885CYP2D6 3147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.