Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | AGER | Q15109 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | DHODH | Q02127 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7822651 | 0.89 | KDM4E (0.54) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL8542675 | 0.87 | KDM4E (0.56) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL7818346 | 0.84 | KMO (0.46) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL7821042 | 0.82 | KDM4E (0.58) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL9172028 | 0.79 | ALDH1A1 (0.61) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL7361696 | 0.78 | L3MBTL1 (0.56) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL10336997 | 0.78 | ALDH1A1 (0.80) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL9166777 | 0.77 | ALDH1A1 (0.62) | KDM4EALDH1A1TSHRCYP3A4MAPT | |
| SCHEMBL17375350 | 0.77 | RECQL (0.50) | ALDH1A1SMN1; SMN2RAB9AKMT2AKMO | |
| SCHEMBL30396748 | 0.76 | ALDH1A1 (0.65) | KDM4EALDH1A1TSHRCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0750619-B1 | HETERO-ANNULATED INDAZOLES | NOVUSPHARMA SPA (IT) | 2001-05-30 | — | — | EP | disclosed |
| US-5596097-A | ANTITUMOR AGENTS | THE UNIVERSITY OF VERMONT (US) | 1997-01-21 | — | — | US | disclosed |
| WO-1995024407-A1 | HETERO-ANNULATED INDAZOLES | BOEHRINGER MANNHEIM ITALIA, S.P.A. (IT) | 1995-09-14 | — | — | WO | disclosed |