Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830852 | 0.94 | CCNB2 (0.43) | LGMNADORA3ADORA2BCCNB2CDK1 | |
| SCHEMBL7834893 | 0.87 | POLB (0.44) | ADORA3ADORA2BTP53CCNB2CDK1 | |
| SCHEMBL7821723 | 0.86 | LMNA (0.50) | LGMNTP53CCNB2CDK1CCNB1 | |
| SCHEMBL11196780 | 0.77 | KDM4E (0.49) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL7831973 | 0.77 | KMT2A (0.55) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL7830685 | 0.77 | KMT2A (0.58) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL7835021 | 0.76 | MAPT (0.41) | ADORA3ADORA2BCCNB2CDK1CCNB1 | |
| SCHEMBL7830310 | 0.76 | MEN1 (0.48) | ADORA3ADORA2BPKMRAB9ASMN1; SMN2 | |
| SCHEMBL7835524 | 0.76 | ADORA3 (0.46) | ADORA3ADORA2BCCNB2CDK1CCNB1 | |
| SCHEMBL7847076 | 0.76 | ADORA3 (0.41) | LGMNADORA3ADORA2BCCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |