Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 6/20 | 0.50 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.50 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824138 | 0.94 | PDE4A (0.46) | SLC9A1SLC9A3SLC9A2PDE4APDE4B | |
| SCHEMBL7822459 | 0.86 | PDE4A (0.40) | SLC9A1SLC9A3SLC9A2PDE4APDE4B | |
| SCHEMBL7822660 | 0.84 | SLC9A1 (0.59) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL27401335 | 0.84 | SLC9A1 (0.59) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL7823170 | 0.81 | SLC9A1 (0.50) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8700581 | 0.80 | ALDH1A1 (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7815979 | 0.79 | SLC9A1 (0.47) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL7830336 | 0.77 | SLC9A1 (0.47) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8707718 | 0.77 | SLC9A1 (0.49) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL7823135 | 0.77 | SLC9A1 (0.40) | SLC9A1SLC9A3SLC9A2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699185-B1 | GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-09-05 | — | — | EP | disclosed |