SCHEMBL782256

SCHEMBL782256

CC(C)(C)c1ccc(-c2nnc(-c3ccc(-c4ccc(C(=O)CC(=O)C(F)(F)F)cc4)cc3)o2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR1H4 Q96RI1 1/20 0.49
▸ PLOD2 O00469 2/20 0.48
▸ TP53 P04637 2/20 0.47
▸ NPC1 O15118 4/20 0.47
▸ RAB9A P51151 4/20 0.47
▸ MAPT P10636 3/20 0.47
▸ PLOD3 O60568 1/20 0.47
▸ PLOD1 Q02809 1/20 0.47
▸ ALDH1A1 P00352 3/20 0.47
▸ KDM4E B2RXH2 2/20 0.47
▸ S1PR1 P21453 2/20 0.46
▸ S1PR4 O95977 1/20 0.46
▸ S1PR5 Q9H228 1/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ CYP1A2 P05177 1/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ CYP2C9 P11712 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45
▸ IKBKB O14920 2/20 0.44
▸ HSD17B10 Q99714 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28718057 0.84 PLOD2 (0.66) NR1H4PLOD2TP53NPC1RAB9A
SCHEMBL12920452 0.79 KDM4E (0.65) NR1H4TP53NPC1RAB9AMAPT
SCHEMBL21760737 0.78 NPC1 (0.66) NR1H4NPC1RAB9AKDM4ES1PR1
SCHEMBL13894195 0.78 IKBKB (0.56) NR1H4TP53NPC1RAB9AMAPT
SCHEMBL12920431 0.77 RAB9A (0.54) NR1H4TP53NPC1RAB9AMAPT
SCHEMBL5206623 0.77 NPC1 (0.68) NR1H4NPC1RAB9AMAPTALDH1A1
SCHEMBL5676017 0.76 PLOD2 (0.64) PLOD2PLOD3PLOD1HDAC1HDAC8
SCHEMBL967102 0.76 SMN1; SMN2 (0.59) NR1H4TP53NPC1RAB9AMAPT
SCHEMBL29623599 0.76 PLOD2 (0.55) NR1H4PLOD2NPC1RAB9AMAPT
SCHEMBL968069 0.76 SMN1; SMN2 (0.59) NR1H4TP53NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8734953-B2 Laminated glass panel for head-up display system SAINT-GOBAIN GLASS FRANCE (FR) 2014-05-27 — — US disclosed
US-20130252001-A1 LAMINATED GLASS PANEL FOR HEAD-UP DISPLAY SYSTEM SAINT-GOBAIN GLASS FRANCE (FR) 2013-09-26 — — US disclosed
US-8487277-B2 Laminated glass panel for a heads-up display system SAINT-GOBAIN GLASS FRANCE (FR) 2013-07-16 — — US disclosed
US-20120068083-A1 LAMINATED GLASS PANEL FOR A HEADS-UP DISPLAY SYSTEM SAINT-GOBAIN GLASS FRANCE (FR) 2012-03-22 — — US disclosed
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