Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828177 | 0.82 | AKR1C3 (0.47) | AKR1C3PTGER4ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL7816139 | 0.79 | ALOX15 (0.51) | AKR1C3PTGER4ALDH1A1HTTALOX15 | |
| SCHEMBL7829626 | 0.78 | AKR1C3 (0.49) | AKR1C3PTGER4ALDH1A1HTTALOX15 | |
| SCHEMBL7816497 | 0.76 | AKR1C3 (0.49) | AKR1C3PTGER4ALDH1A1HTTALOX15 | |
| SCHEMBL7828179 | 0.76 | AKR1C3 (0.53) | AKR1C3PTGER4ALDH1A1HTTKMT2A | |
| SCHEMBL7815954 | 0.76 | HPGD (0.50) | AKR1C3PTGER4ALDH1A1HTTALOX15 | |
| SCHEMBL7826600 | 0.75 | ALOX15 (0.47) | AKR1C3ALDH1A1ALOX15L3MBTL1CYP1A2 | |
| SCHEMBL7836319 | 0.75 | ALOX15 (0.48) | AKR1C3PTGER4ALDH1A1ALOX15L3MBTL1 | |
| SCHEMBL7824961 | 0.74 | CYP19A1 (0.46) | AKR1C3ALDH1A1CYP1A2SMN1; SMN2LMNA | |
| SCHEMBL5519388 | 0.74 | POLB (0.52) | AKR1C3ALDH1A1ALOX15L3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| US-5840895-A | INTERMEDIATES FOR ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1998-11-24 | — | — | US | disclosed |
| US-5686442-A | ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |