Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.47 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824961 | 0.91 | CYP19A1 (0.46) | AKR1C3TACR3ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL7829626 | 0.87 | AKR1C3 (0.49) | AKR1C3ALDH1A1NPSR1HSD17B10POLB | |
| SCHEMBL7828179 | 0.86 | AKR1C3 (0.53) | AKR1C3ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL7822920 | 0.82 | AKR1C3 (0.42) | AKR1C3ALDH1A1PTGER4ALOX15L3MBTL1 | |
| SCHEMBL8073356 | 0.81 | AKR1C3 (0.47) | AKR1C3TACR3ALDH1A1MAPTRAF1 | |
| SCHEMBL7816139 | 0.81 | ALOX15 (0.51) | AKR1C3ALDH1A1HSD17B10NPC1RAB9A | |
| SCHEMBL7824962 | 0.79 | AKR1C3 (0.51) | AKR1C3ALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL8073566 | 0.79 | CASP3 (0.44) | AKR1C3HSD17B10MAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL7815954 | 0.77 | HPGD (0.50) | AKR1C3ALDH1A1MAPTPTGER4ALOX15 | |
| SCHEMBL7826600 | 0.77 | ALOX15 (0.47) | AKR1C3ALDH1A1HSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| US-5840895-A | INTERMEDIATES FOR ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1998-11-24 | — | — | US | disclosed |
| US-5686442-A | ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |