Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE8B | O95263 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828177 | 0.87 | AKR1C3 (0.47) | AKR1C3ALOX15L3MBTL1PTGER4POLB | |
| SCHEMBL7816139 | 0.85 | ALOX15 (0.51) | AKR1C3ALOX15L3MBTL1PTGER4POLB | |
| SCHEMBL7815954 | 0.82 | HPGD (0.50) | AKR1C3ALOX15L3MBTL1PTGER4MAPT | |
| SCHEMBL7829631 | 0.81 | AKR1C3 (0.51) | AKR1C3ALOX15L3MBTL1PTGER4POLB | |
| SCHEMBL7836319 | 0.81 | ALOX15 (0.48) | AKR1C3ALOX15L3MBTL1PTGER4POLB | |
| SCHEMBL7824961 | 0.80 | CYP19A1 (0.46) | AKR1C3MAPTCYP1A2SMN1; SMN2NPSR1 | |
| SCHEMBL5519388 | 0.80 | POLB (0.52) | AKR1C3ALOX15L3MBTL1POLBMAPT | |
| SCHEMBL7826820 | 0.80 | ALOX15 (0.49) | AKR1C3ALOX15L3MBTL1PTGER4POLB | |
| SCHEMBL7823476 | 0.78 | HPGD (0.52) | AKR1C3ALOX15L3MBTL1PTGER4POLB | |
| SCHEMBL7822920 | 0.78 | AKR1C3 (0.42) | AKR1C3ALOX15L3MBTL1PTGER4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| US-5840895-A | INTERMEDIATES FOR ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1998-11-24 | — | — | US | disclosed |
| US-5686442-A | ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |