SCHEMBL7824045

SCHEMBL7824045

O=C(O)c1ccncc1C(=O)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 3/20 0.62
KDM4C Q9H3R0 7/20 0.57
KDM4D Q6B0I6 4/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
KDM4E B2RXH2 3/20 0.53
ALDH1A1 P00352 4/20 0.52
KDM6B O15054 4/20 0.52
KDM4A O75164 2/20 0.52
MAPT P10636 1/20 0.52
THRB P10828 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
CDC25B P30305 2/20 0.50
APP P05067 1/20 0.50
GAA P10253 1/20 0.50
HCAR3 P49019 1/20 0.50
HCAR2 Q8TDS4 1/20 0.50
ATM Q13315 1/20 0.50
NR4A1 P22736 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7850570 0.93 AKR1C3 (0.62) AKR1C3KDM4CKDM4DMEN1KMT2A
SCHEMBL7843027 0.84 LTA4H (0.58) AKR1C3KDM4CKDM4DMEN1KMT2A
SCHEMBL1040762 0.84 NR4A1 (0.62) AKR1C3KDM4CKDM4DMEN1KMT2A
SCHEMBL21056719 0.82 KDM4C (0.54) AKR1C3KDM4CKDM4DMEN1KMT2A
SCHEMBL71335 0.82 KDM4C (0.65) KDM4CKDM4DMEN1KMT2AKDM4E
SCHEMBL29416303 0.82 KDM4C (0.65) KDM4CKDM4DMEN1KMT2AKDM4E
SCHEMBL28854487 0.81 KMT2A (0.57) AKR1C3KDM4CKDM4DMEN1KMT2A
SCHEMBL8864740 0.81 AKR1C3 (0.73) AKR1C3MEN1KMT2AKDM4EALDH1A1
SCHEMBL20385461 0.80 KMT2A (0.55) AKR1C3KDM4CKDM4DMEN1KMT2A
SCHEMBL5700207 0.80 KMT2A (0.55) AKR1C3KDM4CKDM4DMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-53081626-A None JP disclosed
JP-53081626-A None JP disclosed
EP-0652218-B1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2001-07-11 EP disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
CN-1052004-C Heterocyclic compounds, their production and use TALCEDA CHEMICAL IND LTD (JP) 2000-05-03 CN disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed
US-5585385-A USEFUL IN TREATING DISORDERS OF MICTURITION; ADMINISTERING TO INHIBIT PLASMA EXTRAVASATION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-12-17 US disclosed
US-5512564-A VIRICIDES, AIDS BOEHRINGER MANNHEIM GMBH (DE) 1996-04-30 US disclosed
EP-0602097-B1 TRICYCLIC THIAZOL AND OXAZOL DERIVATES WITH ANTIVIRAL ACTION BOEHRINGER MANNHEIM GMBH (DE) 1996-04-24 EP disclosed
CN-1107476-A Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1995-08-30 CN disclosed
EP-0652218-A1 Heterocyclic compounds, their production and use Takeda Chemical Industries, Ltd. (JP) 1995-05-10 EP disclosed
EP-0602097-A1 NEW TRICYCLIC THIAZOL AND OXAZOL DERIVATES WITH ANTIVIRAL ACTION. BOEHRINGER MANNHEIM GMBH (DE) 1994-06-22 EP disclosed
WO-1993005047-A1 NEW TRICYCLIC THIAZOL AND OXAZOL DERIVATES WITH ANTIVIRAL ACTION BOEHRINGER MANNHEIM GMBH (DE) 1993-03-18 WO disclosed
JP-S5381626-A ANTITHROMBOTICS COMPOSITION BENZOYL ISONICOTINIC ACID AS A MAIN COMPONENT KYOWA HAKKO KOGYO CO LTD 1978-07-19 JP disclosed
JP-S5381626-A ANTITHROMBOTICS COMPOSITION BENZOYL ISONICOTINIC ACID AS A MAIN COMPONENT KYOWA HAKKO KOGYO CO LTD 1978-07-19 JP disclosed