Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.49 |
| ▸ | KDM5A | P29375 | 1/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824045 | 0.84 | AKR1C3 (0.62) | NR4A1KDM4CKMT2AKDM4DKDM4E | |
| SCHEMBL7843027 | 0.83 | LTA4H (0.58) | NR4A1KDM4CKMT2AKDM4DKDM4E | |
| SCHEMBL1921967 | 0.83 | ROCK2 (0.50) | NR4A1SRD5A2KMT2AKDM4EMEN1 | |
| SCHEMBL7804698 | 0.78 | TGFBR1 (0.47) | KDM4CKDM5AKDM5BKMT2AKDM4D | |
| SCHEMBL71335 | 0.78 | KDM4C (0.65) | KDM4CKMT2AKDM4DKDM4EMEN1 | |
| SCHEMBL29416303 | 0.78 | KDM4C (0.65) | KDM4CKMT2AKDM4DKDM4EMEN1 | |
| SCHEMBL7850570 | 0.77 | AKR1C3 (0.62) | NR4A1KDM4CKMT2AKDM4DKDM4E | |
| SCHEMBL30884880 | 0.77 | NR4A1 (1.00) | NR4A1SRD5A2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1247787 | 0.77 | NR4A1 (1.00) | NR4A1SRD5A2KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL7855298 | 0.77 | LTA4H (0.58) | NR4A1KDM4CKMT2AKDM4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140051689-A1 | Polycyclic Agents for the Treatment of Respiratory Syncytial Virus Infections | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2014-02-20 | — | — | US | disclosed |
| US-8598193-B2 | Polycyclic agents for the treatment of respiratory syncytial virus infections | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2013-12-03 | — | — | US | disclosed |
| CN-101723949-B | Polycyclic agents for treatment of respiratory syncytial virus infections | BIOTA SCIENT MAN | 2013-10-23 | — | — | CN | disclosed |
| EP-2287167-A1 | Polycyclic agents for the treatment of respiratory syncytial virus infections | BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) | 2011-02-23 | — | — | EP | disclosed |
| EP-1697377-B1 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENT MANAGEMENT (AU) | 2011-01-26 | — | — | EP | disclosed |
| EP-1697377-A4 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENT MANAGEMENT (AU) | 2008-03-19 | — | — | EP | disclosed |
| US-20070287700-A1 | Polycyclic agents for the treatment of respiratory syncytial virus infections | BIOTA SCIENTFIC MANAGEMENMT PTY LTD. (AU) | 2007-12-13 | — | — | US | disclosed |
| EP-1697377-A1 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061513-A1 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051689-A1 | Polycyclic Agents for the Treatment of Respiratory Syncytial Virus Infections | SDHA, SDHB, NDUFB7 | NR4A1 321/4885SRD5A2 1196/4885KDM4C 2064/4885 |
| US-20070287700-A1 | Polycyclic agents for the treatment of respiratory syncytial virus infections | PAICS, SDHB, SDHA | NR4A1 242/4885SRD5A2 1499/4885KDM4C 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.