Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020015 | 0.92 | P2RX7 (0.33) | ALDH1A1GAAP2RX7MAPTHTT | |
| SCHEMBL8013600 | 0.91 | ALDH1A1 (0.36) | ALDH1A1GAAP2RX7MAPTHTT | |
| SCHEMBL7845523 | 0.88 | ALDH1A1 (0.34) | ALDH1A1GAAP2RX7MAPTHTT | |
| SCHEMBL8099222 | 0.86 | GAA (0.38) | ALDH1A1GAAP2RX7MAPTHTT | |
| SCHEMBL8090703 | 0.85 | GAA (0.33) | ALDH1A1GAAP2RX7MAPTHTT | |
| SCHEMBL7819659 | 0.84 | ALDH1A1 (0.36) | ALDH1A1GAAP2RX7MAPTHTT | |
| SCHEMBL8593496 | 0.83 | ALDH1A1 (0.34) | ALDH1A1GAAP2RX7MAPTHTT | |
| SCHEMBL8012714 | 0.82 | GAA (0.36) | ALDH1A1GAAP2RX7MAPTHSD17B10 | |
| SCHEMBL8017443 | 0.82 | FGFR1 (0.31) | ALDH1A1GAAFGFR1FLT1FGFR3 | |
| SCHEMBL8015909 | 0.81 | PARP1 (0.36) | ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880522-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES AMPA AND NMDA RECEPTORS ANTAGONISTS, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | disclosed |
| EP-0880522-A1 | 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997025328-A1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1997-07-17 | — | — | WO | disclosed |