Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845523 | 0.91 | ALDH1A1 (0.34) | GAAALDH1A1P2RX7MAPTHTT | |
| SCHEMBL8020015 | 0.87 | P2RX7 (0.33) | GAAALDH1A1P2RX7MAPTHTT | |
| SCHEMBL8013600 | 0.86 | ALDH1A1 (0.36) | GAAALDH1A1P2RX7MAPTHTT | |
| SCHEMBL8099222 | 0.86 | GAA (0.38) | GAAALDH1A1P2RX7MAPTHTT | |
| SCHEMBL7824847 | 0.85 | ALDH1A1 (0.33) | GAAALDH1A1P2RX7MAPTHTT | |
| SCHEMBL8593496 | 0.83 | ALDH1A1 (0.34) | GAAALDH1A1P2RX7MAPTHTT | |
| SCHEMBL8012714 | 0.82 | GAA (0.36) | GAAALDH1A1P2RX7MAPTHSD17B10 | |
| SCHEMBL8015909 | 0.81 | PARP1 (0.36) | GAAALDH1A1MAPT | |
| SCHEMBL7835755 | 0.81 | ALDH1A1 (0.36) | GAAALDH1A1P2RX7MAPTHTT | |
| SCHEMBL8011799 | 0.80 | CYP1A2 (0.32) | GAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057454-A | USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS | RHONE-POULENC RORER S.A. (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |