Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | BCL2 | P10415 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011792 | 0.90 | GAA (0.36) | ALDH1A1KDM4ECYP1A2GAA | |
| SCHEMBL8020015 | 0.89 | P2RX7 (0.33) | ALDH1A1GAA | |
| SCHEMBL8011799 | 0.89 | CYP1A2 (0.32) | ALDH1A1SMN1; SMN2CYP1A2GAALMNA | |
| SCHEMBL7824847 | 0.82 | ALDH1A1 (0.33) | FGFR1FLT1FGFR3ALDH1A1GAA | |
| SCHEMBL7823416 | 0.81 | — | — | |
| SCHEMBL8013600 | 0.81 | ALDH1A1 (0.36) | FGFR1FLT1FGFR3ALDH1A1KDM4E | |
| SCHEMBL8090703 | 0.79 | GAA (0.33) | ALDH1A1GAA | |
| SCHEMBL7845523 | 0.77 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2CYP1A2GAALMNA | |
| SCHEMBL8099222 | 0.76 | GAA (0.38) | ALDH1A1KDM4ECYP1A2GAA | |
| SCHEMBL8013343 | 0.76 | GAA (0.38) | ALDH1A1KDM4ESMN1; SMN2CYP1A2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100264-A | 5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them | RHONE-POULENC RORER, S.A. (FR) | 2000-08-08 | — | — | US | disclosed |