Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23798257 | 0.82 | YAP1 (0.58) | YAP1HTTKDM4EPKMKMT2A | |
| SCHEMBL7825211 | 0.82 | ITGB3 (0.51) | — | |
| SCHEMBL7824541 | 0.81 | CCR1 (0.51) | YAP1HTTKDM4EPKMSIGMAR1 | |
| SCHEMBL6497079 | 0.80 | SMN1; SMN2 (0.54) | YAP1HTTKDM4EPKMKMT2A | |
| SCHEMBL25502060 | 0.78 | KDM4E (0.52) | YAP1HTTKDM4EPKMKMT2A | |
| SCHEMBL25502059 | 0.78 | KDM4E (0.52) | YAP1HTTKDM4EPKMKMT2A | |
| SCHEMBL30312922 | 0.78 | KDM4E (0.52) | YAP1HTTKDM4EPKMKMT2A | |
| SCHEMBL25819172 | 0.77 | ACACB (0.51) | KMT2A | |
| SCHEMBL2186640 | 0.77 | FKBP1A (0.47) | CTSLKMT2AFKBP1ANPC1RAB9A | |
| SCHEMBL8791458 | 0.75 | SMN1; SMN2 (0.50) | YAP1SIGMAR1GRIN2BNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800516-B1 | FIBRINOGEN RECEPTOR ANTAGONISTS HAVING SUBSTITUTED (b)-AMINO ACID RESIDUES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | NIPPON STEEL CORP (JP) | 2001-09-19 | — | — | EP | disclosed |
| US-5866592-A | Fibrinogen receptor antagonist and pharmaceutical compositions comprising the same | NIPPON STEEL CORPORATION (JP) | 1999-02-02 | — | — | US | disclosed |