Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | PTPRCAP | Q14761 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637762 | 0.65 | DRD2 (0.36) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL7805133 | 0.65 | DRD2 (0.55) | ADRA1DADRA1AADRA1BDRD2DRD3 | |
| SCHEMBL7805273 | 0.64 | HTR3A (0.49) | ADRA1BDRD2DRD3TGFBR1ACVR1 | |
| SCHEMBL8637498 | 0.60 | POLB (0.41) | HTR2C | |
| SCHEMBL13155986 | 0.58 | CYP19A1 (0.50) | ADRA1DADRA1AADRA1BCHRM2CHRM1 | |
| SCHEMBL23369049 | 0.58 | CYP3A4 (0.57) | ADRA1DADRA1AADRA1BCHRM2CHRM1 | |
| SCHEMBL23368901 | 0.58 | CYP3A4 (0.57) | ADRA1DADRA1AADRA1BCHRM2CHRM1 | |
| SCHEMBL7812109 | 0.57 | CHRNB2 (0.39) | DRD2DRD3HTR2C | |
| SCHEMBL9086137 | 0.57 | ERN1 (0.46) | DRD2DRD1ACHE | |
| SCHEMBL5722666 | 0.57 | HTR2C (0.50) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745598-B1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-08-22 | — | — | EP | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |