Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 3/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638929 | 0.76 | HTR1A (0.50) | DRD2SIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL7805133 | 0.74 | DRD2 (0.55) | DRD2SIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL8638400 | 0.70 | PDCD1 (0.32) | DRD2SIGMAR1HTR1ADRD3HTR2A | |
| SCHEMBL8638972 | 0.68 | PDCD1 (0.46) | DRD2SIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL7805201 | 0.68 | HTR2C (0.43) | DRD2SIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL7805273 | 0.67 | HTR3A (0.49) | DRD2SIGMAR1HTR1AADRA1BDRD3 | |
| SCHEMBL7811838 | 0.66 | HTR2C (0.48) | HTR2CKCNH2 | |
| SCHEMBL7826532 | 0.65 | ADRA1D (0.33) | DRD2SIGMAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL8637881 | 0.64 | KCNH2 (0.34) | KCNH2 | |
| SCHEMBL7822917 | 0.64 | HTR2C (0.41) | HTR1AADRA1AADRA2AADRA2CHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |