Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.59 |
| ▸ | FABP2 | P12104 | 1/20 | 0.59 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1211557 | 1.00 | PTGS2 (1.00) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Hydrochloric Acid SCHEMBL5753890 | 0.98 | PTGS2 (0.96) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL917093 | 0.93 | PTGS2 (0.87) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL17524311 | 0.89 | PTGS2 (0.81) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL23581099 | 0.86 | PTGS2 (0.75) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL66842 | 0.86 | PTGS2 (0.75) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Benzene SCHEMBL28145708 | 0.86 | PTGS2 (0.75) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL10411845 | 0.86 | PTGS2 (0.75) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| SCHEMBL3418 | 0.86 | PTGS2 (0.75) | PTGS2PTGS1AKR1C3LMNACYP2C9 | |
| Iodide SCHEMBL3868944 | 0.86 | PTGS2 (0.75) | PTGS2PTGS1AKR1C3LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160038448-A1 | THE INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURBIPROFEN AND FLURBIPROFEN DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2016-02-11 | — | — | US | disclosed |
| US-20160038448-A1 | THE INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURBIPROFEN AND FLURBIPROFEN DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2016-02-11 | — | — | US | disclosed |
| WO-2014159772-A2 | INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURIPROFEN AND FLURIPROFEN DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATW UNIVERSITY OF NEW YORK (US) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014159772-A2 | INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURIPROFEN AND FLURIPROFEN DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATW UNIVERSITY OF NEW YORK (US) | 2014-10-02 | — | — | WO | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160038448-A1 | THE INHIBITION OF THE TOXIC EFFECTS OF ISLET AMYLOID FORMATION BY FLURBIPROFEN AND FLURBIPROFEN DERIVATIVES | IAPP, AMY2A, APP | PTGS2 2081/4885PTGS1 1077/4885AKR1C3 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.