Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831952 | 0.89 | HSD11B1 (0.52) | HSD11B1POLBMAPTLMNA | |
| SCHEMBL7817798 | 0.87 | HSD11B1 (0.41) | HSD11B1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL7336087 | 0.86 | HSD11B1 (0.52) | HSD11B1POLBHTTMAPTMEN1 | |
| SCHEMBL7832196 | 0.82 | HSD11B1 (0.43) | HSD11B1POLBHTTMAPTLMNA | |
| SCHEMBL7824156 | 0.82 | ALDH1A1 (0.46) | HSD11B1POLBHTTMAPTMEN1 | |
| SCHEMBL7825737 | 0.82 | HSD11B1 (0.52) | HSD11B1POLBMAPTSMN1; SMN2TP53 | |
| SCHEMBL7828653 | 0.81 | HSD11B1 (0.48) | HSD11B1POLBMAPTSMN1; SMN2 | |
| SCHEMBL7831589 | 0.79 | HSD11B1 (0.49) | HSD11B1POLBHTTMAPTSMN1; SMN2 | |
| SCHEMBL7826317 | 0.78 | HSD11B1 (0.50) | HSD11B1POLBMAPTSMN1; SMN2TP53 | |
| SCHEMBL7827530 | 0.78 | HSD11B1 (0.43) | HSD11B1POLBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |