Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | USP9X | Q93008 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824156 | 0.95 | ALDH1A1 (0.46) | HSD11B1ALDH1A1L3MBTL1HTTMAPT | |
| SCHEMBL7341323 | 0.87 | HSD11B1 (0.49) | HSD11B1NPC1HSP90AA1RAB9APAX8 | |
| SCHEMBL7831952 | 0.86 | HSD11B1 (0.52) | HSD11B1GAAMAPTPOLBLMNA | |
| SCHEMBL7829083 | 0.86 | POLB (0.42) | ALDH1A1POLBLMNA | |
| SCHEMBL7824055 | 0.86 | POLB (0.42) | ALDH1A1L3MBTL1HTTPOLBLMNA | |
| SCHEMBL7817798 | 0.84 | HSD11B1 (0.41) | HSD11B1ALDH1A1L3MBTL1MAPTLMNA | |
| SCHEMBL7827530 | 0.83 | HSD11B1 (0.43) | HSD11B1NPC1HSP90AA1RAB9APAX8 | |
| SCHEMBL7827728 | 0.83 | EDNRB (0.42) | NPC1RAB9AGAAHTTMAPT | |
| SCHEMBL7826340 | 0.83 | EDNRB (0.42) | NPC1RAB9AALDH1A1L3MBTL1HTT | |
| SCHEMBL7334097 | 0.82 | HSD11B1 (0.49) | HSD11B1ALDH1A1L3MBTL1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |