Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EDNRA | P25101 | 4/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | EDNRB | P24530 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824156 | 0.89 | ALDH1A1 (0.46) | HSD11B1LMNAMEN1KMT2AEDNRA | |
| SCHEMBL7334114 | 0.89 | HSD11B1 (0.46) | HSD11B1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL7827115 | 0.87 | HSD11B1 (0.46) | HSD11B1LMNAMAPK1MEN1KMT2A | |
| SCHEMBL7832196 | 0.84 | HSD11B1 (0.43) | HSD11B1LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7827530 | 0.84 | HSD11B1 (0.43) | HSD11B1EDNRAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL7831952 | 0.84 | HSD11B1 (0.52) | HSD11B1LMNAMAPT | |
| SCHEMBL7829083 | 0.82 | POLB (0.42) | LMNAKMT2AEDNRAALDH1A1EDNRB | |
| SCHEMBL7824055 | 0.82 | POLB (0.42) | LMNAKMT2AEDNRAALDH1A1L3MBTL1 | |
| SCHEMBL7817130 | 0.81 | EDNRB (0.45) | LMNAMAPK1EDNRAMAPTALDH1A1 | |
| SCHEMBL7828653 | 0.78 | HSD11B1 (0.48) | HSD11B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |