Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228474 | 0.80 | ALDH1A1 (0.52) | THRBHTTLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL7322311 | 0.80 | THRB (0.49) | THRBHTTLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL6618068 | 0.80 | ADRB1 (0.52) | THRBLMNASMN1; SMN2KCNH2HRH3 | |
| SCHEMBL7840859 | 0.80 | ESR2 (0.47) | THRBHTTLMNASMN1; SMN2L3MBTL1 | |
| Bromide SCHEMBL6539610 | 0.79 | ADRB1 (0.50) | THRBLMNASMN1; SMN2KCNH2HRH3 | |
| SCHEMBL7827690 | 0.79 | THRB (0.48) | THRBHTTLMNASMN1; SMN2HRH3 | |
| SCHEMBL23064493 | 0.78 | L3MBTL1 (0.52) | THRBHTTLMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL23655563 | 0.76 | THRB (0.49) | THRBHTTLMNASMN1; SMN2KCNH2 | |
| SCHEMBL7333118 | 0.76 | KDM4E (0.56) | THRBKCNH2HRH3KDM4ETP53 | |
| SCHEMBL6616137 | 0.76 | MAPT (0.56) | THRBHTTLMNASMN1; SMN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102762-A2 | 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER INC. (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008013-A2 | 2-SUBSTITUTED-1-PIPERIDYL BENZIMIDAZOLE COMPOUNDS AS ORL1-RECEPTOR AGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-02-17 | — | — | WO | disclosed |